PROGRAM INTRODUCTION


The Autism Genetic Resource Exchange (AGRE) is a non-profit DNA repository and family registry housing a database of genotypic and phenotypic information that is available to autism researchers worldwide. AGRE is an unprecedented resource for the study of autism genetics.

AGRE believes that complex neuropsychiatric diseases such as autism are best approached through collaborative research efforts that pool large sample sizes to accelerate the pace of research. The goal of AGRE is to facilitate more rapid progress in the identification of the genetic underpinnings of autism spectrum disorders by making this information available to the scientific community. This substantial collection, which has now grown to over 1300 multiplex and simplex pedigrees, has clearly moved the field in that direction. AGRE has been cited in over 180 papers in the last ten years.

Program highlights include:

Genotypic Data

  • High-density SNP
  • Whole Genome Scan and Finemapping
  • Genome-wide High-density 10K SNP data on 426 families from the Autism Genome Project (AGP)
  • Cell lines, DNA and plasma are available for purchase

Phenotypic Data

  • ADI-R and ADOS testing results with all interview data points and computer scored algorithm
  • Cognitive assessments and other interview forms/questionnaires
  • Medical histories, environmental exposure histories, and physical neurological exam data are available for a subset of our population

Additional Program Highlights:

  • ISAAC’s data management system is available to researchers through AGRE. The system is web-based, enabling easy collaboration, user and patient management and data sharing.

  • In 2009, AGRE began collecting parent-report assessments through the Online System for Clinical Research (OSCR). OSCR was developed as a tool to accelerate the pace of research and keep families involved in the process. OSCR allows our team to get information to scientists quickly through a series of online questionnaires that are continually updated in an effort to quicken the pace of autism research.

Copyright © 2018 Autism Speaks, all rights reserved.